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Natural killer cell lines in tumor immunotherapy

Min Cheng, Jian Zhang, Wen Jiang, Yongyan Chen, Zhigang Tian

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 56-66 doi: 10.1007/s11684-012-0177-7

Abstract:

Natural killer (NK) cells are considered to be critical players in anticancer immunity.However, cancers are able to develop mechanisms to escape NK cell attack or to induce defective NK cellsCurrent NK cell-based cancer immunotherapy is aimed at overcoming NK cell paralysis through several potentiallines and genetically modifying fresh NK cells or NK cell lines.The stable allogeneic NK cell line approach is more practical for quality-control and large-scale production

Keywords： natural killer cell     natural killer cell line     tumor immunotherapy     genetic modification    

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Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 269-279 doi: 10.1007/s11684-018-0621-4

Abstract: The liver contains a large proportion of natural killer (NK) cells, which exhibit heterogeneity in phenotypicNK cell activation, well known for its role in the immune surveillance against tumor and pathogen-infectedIn addition to the innate direct “killer” functions, NK cell activity contributes to regulateHere, we focus on the relationship between NK cell biology, such as their phenotypic features and functional

Keywords： natural killer cell     phenotype     immune activation     immune tolerance     liver diseases    

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Natural killer cells in hepatocellular carcinoma: current status and perspectives for future immunotherapeutic

Min Yu, Zonghai Li

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 509-521 doi: 10.1007/s11684-017-0546-3

Abstract: the liver and in the immune defenses against HCC, indicating that HCC might be an ideal target for NK cell-basedpaper summarizes current knowledge on NK cells in HCC and discusses the usefulness and prospects of NK cell-basedCritical issues that require consideration for the successful clinical translation of NK cell-based therapiesIf appropriately used and further optimized, NK cell-based therapies could dominate important roles in

Keywords： natural killer cell     hepatocellular carcinoma     immunotherapy    

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Astragaloside IV suppresses post-ischemic natural killer cell infiltration and activation in the brain

Baokai Dou, Shichun Li, Luyao Wei, Lixin Wang, Shiguo Zhu, Zhengtao Wang, Zunji Ke, Kaixian Chen, Zhifei Wang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 79-90 doi: 10.1007/s11684-020-0783-8

Abstract: Natural killer (NK) cells, a type of cytotoxic lymphocytes, can infiltrate into ischemic brain and exacerbateneuronal cell death.Strikingly, ASIV reversed NK cell deficiency in the spleen and blood after brain ischemia.Meanwhile, ASIV attenuated NK cell activating receptor NKG2D levels and reduced interferon-γ productionFurthermore, ASIV’s effects on suppressing NK cell brain infiltration and activation may involve HDAC

Keywords： astragaloside IV     brain ischemia     natural killer cells     histone deacetylase     nuclear factor-κB    

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Natural Killer Cell-Based Immunotherapy for Cancer: Advances and Prospects Review

Yuan Hu, Zhigang Tian, Cai Zhang

Engineering 2019, Volume 5, Issue 1,   Pages 106-114 doi: 10.1016/j.eng.2018.11.015

Abstract:

Natural killer (NK) cells are key innate immune cells that provide the first line of defense againsttransformed cells and malignancies in real time, tumors develop several strategies to escape from NK cellincluding autologous or allogeneic NK cells, umbilical cord blood (UCB) or induced pluripotent stem cell(iPSC)-derived NK cells, memory-like NK cells, and NK cell line NK-92 cells, for the treatment of differentand advanced progress of NK cell-based immunotherapy, ways of enhancing the antitumor capacity of NK

Keywords： Natural killer cell     Immunotherapy     Cancer     Clinical trial     Chimeric antigen receptor    

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Challenges of NK cell-based immunotherapy in the new era

Fang Fang, Weihua Xiao, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 440-450 doi: tzg@ustc.edu.cn

Abstract:

Natural killer cells (NKs) have a great potential for cancer immunotherapy because they can rapidlyVarious cellular sources, including peripheral blood mononuclear cells (PBMCs), stem cells, and NK cellHowever, considering the safety, activities, and reliability of the cell products, researchers must developIn this review, the challenges on NK cell-based therapeutic approaches and clinical outcomes are discussed

Keywords： natural killer cells     immunotherapy     adoptive transfer     genetic modification     immune checkpoint inhibitor    

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Study of recombinant human IFN-α-2b bacilli Calmette–Guerin activated killer cells and against bladdercancer cell in vitro

FAN Xiaodong, HAN Ruifa

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 377-380 doi: 10.1007/s11684-007-0073-8

Abstract: monocytes (PBMC) were stimulated by recombinant BCG and transformed into bacilli Calmette–Guerin activated killer

Keywords： Urology     powerful     2b-BCG     Tianjin institute     wild-type    

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NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 249-261 doi: 10.1007/s11684-018-0622-3

Abstract:

Natural killer T cells are innate-like and tissue-resident lymphocytes, which recognize lipid antigensNatural killer T cells play important roles in infections, tumors, autoimmune diseases, and metabolicIn this study, we summarize recent findings on biology of natural killer T cells and their roles in hepatitiskiller T cells during the progression of liver diseases, which might be caused by changes in naturalkiller T subsets, factors skewing cytokine responses, and intercellular crosstalk between natural killer

Keywords： natural killer T cells     hepatitis B virus and hepatitis C virus infection     autoimmune liver diseases     alcoholic    

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Establishment and drug sensitivity evaluation of murine ascites hepatocarcinoma cell line with high lymphatic

Hongying ZHANG, Jianwu TANG, Wenting ZHU, Chunxiu HU, Guowang XU

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 119-129 doi: 10.1007/s11684-009-0022-9

Abstract: In order to provide a sensitive cell line model for investigating the mechanisms underlying the lymphaticline with high lymphatic metastatic potential (Hca-P/L ) was established and the effect of curcumininoculated into the medioventral line of a mouse 615 and the first generation of metastatic tumor cellsproliferation of Hca-P and Hca-P/L was observed by inverted microscope, cell growth curve and cellHca-P/L is a novel sensitive cell line model for investigating the mechanisms underlying tumor lymphatic

Keywords： murine ascites hepatocarcinoma cell line     metastasis     curcumin     drug sensitivity    

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Impact of siRNA targeting pirh2 on proliferation and cell cycle control of the lung adenocarcinoma cellline A549

SU Yuan, JIN Yang, ZHANG Xiaoju, ZHOU Qiong, BAI Ming, ZHU Liping

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 359-363 doi: 10.1007/s11684-007-0069-4

Abstract: cycle control of the lung cancer cell line A549.Cell proliferation was assessed by cell counting kit-8 (CCK-8).Taken together, the inhibition of pirh2 expression in the lung adenocarcinoma cell line A549 resultedin reduced tumor cell growth via the inhibition of cell proliferation, the activation of apoptosis andthe interruption of cell cycle transition.

Keywords： control     interruption     cytoplasm     number     growth    

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Anlotinib as third- or further-line therapy for short-term relapsed small-cell lung cancer: subgroup

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 766-772 doi: 10.1007/s11684-021-0916-8

Abstract: Patients with small-cell lung cancer (SCLC) relapse within months after completing previous therapiesThis study aimed to investigate the efficacy and safety of anlotinib as third- or further-line therapyFor patients with short-term relapsed SCLC, third- or further-line anlotinib treatment was associated

Keywords： anlotinib     chemotherapy     short-term relapsed     small-cell lung cancer    

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Hepatitis B virus X protein upregulates tumor necrosis factor-α expression of rat mesangial cellline via ERKs pathway

Hong-Zhu LU MD, Dan LIU BM, Qi-Hong FAN BM, Jian-Hua ZHOU MD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 106-111 doi: 10.1007/s11684-010-0004-y

Abstract: investigate the extracellular regulated protein kinases (ERKs) pathway of HBx on glomerular mesangial cellPCI-neo containing HBV X gene (pCI-neo-X) was then transfected into cultured GMC line via liposome.HBx upregulates TNF-α expression and induces cell proliferation of GMC line partly through ERK signal

Keywords： hepatitis B virus     X gene     glomerular mesangial cell line     extracellular regulated protein kinases     tumor    

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Inhibition of NF-kappa B can enhance Fas-mediated apoptosis in leukemia cell line HL-60

Li WANG, Shi ZHAO, Hong-Xiang WANG, Ping ZOU

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 323-328 doi: 10.1007/s11684-010-0026-5

Abstract: nuclear factor-kappa B (NF-κB) inhibitor Bay 11-7082 on Fas/FasL system and Fas-mediated apoptosis in cellline HL-60 cells.

Keywords： nuclear factor-kappa B     Fas/FasL system     HL-60     Bay 11-7082    

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Acoustic fault signal extraction via the line-defect phononic crystals

Frontiers of Mechanical Engineering 2022, Volume 17, Issue 1,   Pages 10-10 doi: 10.1007/s11465-021-0666-y

Abstract: In this paper, 2D line-defect phononic crystals (PCs) consisting of periodic acrylic tubes with slitThe defect band, namely, the formed resonance band of line-defect PCs enables the incident acoustic waveThe effectiveness of weak harmonic and periodic impulse signal detection via line-defect PCs are investigatedAll the numerical and experimental results indicate that line-defect PCs can be well used for extracting

Keywords： phononic crystals     line-defect     fault signal extraction     acoustic enhancement    

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Calculations of narrow-band transimissities and the Planck mean absorption coefficients of real gases using line-by-line

Huaqiang CHU, Mingyan GU, Huaichun ZHOU, Fengshan LIU

Frontiers in Energy 2014, Volume 8, Issue 1,   Pages 41-48 doi: 10.1007/s11708-013-0292-4

Abstract: the band parameters of Soufiani and Taine, the more recent parameters of André and Vaillon, and the line-by-line

Keywords： transimissity     HITEMP     HITRAN     Planck mean absorption coefficients    

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Title Author Date Type Operation

Natural killer cell lines in tumor immunotherapy

Min Cheng, Jian Zhang, Wen Jiang, Yongyan Chen, Zhigang Tian

Journal Article

Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Journal Article

Natural killer cells in hepatocellular carcinoma: current status and perspectives for future immunotherapeutic

Min Yu, Zonghai Li

Journal Article

Astragaloside IV suppresses post-ischemic natural killer cell infiltration and activation in the brain

Baokai Dou, Shichun Li, Luyao Wei, Lixin Wang, Shiguo Zhu, Zhengtao Wang, Zunji Ke, Kaixian Chen, Zhifei Wang

Journal Article

Natural Killer Cell-Based Immunotherapy for Cancer: Advances and Prospects

Yuan Hu, Zhigang Tian, Cai Zhang

Journal Article

Challenges of NK cell-based immunotherapy in the new era

Fang Fang, Weihua Xiao, Zhigang Tian

Journal Article

Study of recombinant human IFN-α-2b bacilli Calmette–Guerin activated killer cells and against bladdercancer cell in vitro

FAN Xiaodong, HAN Ruifa

Journal Article

NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Journal Article

Establishment and drug sensitivity evaluation of murine ascites hepatocarcinoma cell line with high lymphatic

Hongying ZHANG, Jianwu TANG, Wenting ZHU, Chunxiu HU, Guowang XU

Journal Article

Impact of siRNA targeting pirh2 on proliferation and cell cycle control of the lung adenocarcinoma cellline A549

SU Yuan, JIN Yang, ZHANG Xiaoju, ZHOU Qiong, BAI Ming, ZHU Liping

Journal Article

Anlotinib as third- or further-line therapy for short-term relapsed small-cell lung cancer: subgroup

Journal Article

Hepatitis B virus X protein upregulates tumor necrosis factor-α expression of rat mesangial cellline via ERKs pathway

Hong-Zhu LU MD, Dan LIU BM, Qi-Hong FAN BM, Jian-Hua ZHOU MD,

Journal Article

Inhibition of NF-kappa B can enhance Fas-mediated apoptosis in leukemia cell line HL-60

Li WANG, Shi ZHAO, Hong-Xiang WANG, Ping ZOU

Journal Article

Acoustic fault signal extraction via the line-defect phononic crystals

Journal Article

Calculations of narrow-band transimissities and the Planck mean absorption coefficients of real gases using line-by-line

Huaqiang CHU, Mingyan GU, Huaichun ZHOU, Fengshan LIU

Journal Article